So basically this looks like some issue in connecting with ADS service.
Did you checked your WSDL destination for ADS?
More detailed configuration options can be find in MII configuration guide in https://websmp103.sap-ag.de/~sapidb/011000358700000360702014E (at least ME guide did not mentioned the Certified HTTPS connection setup).
Let me know if it solved your issue. Image may be NSFW.
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