Hi Greg,
Please try these suggestions:
1. Make sure that each Agent Instance has a startup dependency to the OPC Server that you are using (Host Tab, Change Service Dependencies, add KepServerEX 5.xx Runtime)
2. Using the Services control panel applet, set the startup mode for each Agent Instance to Automatic - Delayed Start.
3.
3. Make sure that Kepware 5.xx Runtime service is set to start Automatically (not delayed start).
Regards, Steve